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Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

Categories Pharmaceutical Intermediates
Brand Name: ChineseHormone
Model Number: CAS 57808-66-9
Certification: ISO9001,SGS,UKAS
Place of Origin: China
MOQ: 10g
Price: negotiated
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 500-1000 KG / month
Delivery Time: 3-7 working days
Packaging Details: as your required
Purity: 99%
MW: 425.911
Appearance: White Powder
Water Solubility: 0.0925 mg/mL
MF: C22H24ClN5O2
Shipment: FedEx, TNT, EMS, DHL.UPS,EUB
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Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

Domperidone / Motilium Pharmaceutical Intermediates Stomach Disorders and Antiemetic

Domperidone (INN, USAN, BAN, JAN) (brand name Motilium, many others) is a peripherally selectivedopamine D2 receptor antagonist developed by Janssen Pharmaceutica that is used as an antiemetic,gastroprokinetic agent, and galactogogue.

It may be administered orally or rectally, and is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasing gastrointestinal peristalsis); and to promote lactation(breast milk production) by release of prolactin.

Mechanism of action

Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic:

The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting


This medication increases movement through the digestive system. It is used to treat symptoms of stomach disorders. It may also be used to prevent nausea and vomiting caused by certain medications. Due to safety concerns, this medication is not to be used by breast-feeding women to increase production of breast milk.

How to use

Take this medication by mouth as prescribed usually 30 minutes before meals and at bedtime. Do not increase your dose or take this more often than directed. Your condition will not improve any faster but the risk of side effects will be increased.

Side effects

Headache, dizziness, dry mouth, nervousness, flushing, or irritability may occur the first several days as your body adjusts to the medication. Trouble sleeping, stomach cramps, hot flashes and leg crampshave also been reported.

If any of these effects continue or become bothersome, inform your doctor. Notify your doctor immediately if you develop: chest pain, slow/fast/irregular heartbeat, swelling of the feet or ankles, difficulty urinating, swelling of the breasts or discharge from the nipple in men or women, menstrual changes, sexual difficulties. If you notice other effects not listed above, contact your doctor or pharmacist.

Water Solubility0.0925 mg/mLALOGPS
pKa (Strongest Acidic)12.52ChemAxon
pKa (Strongest Basic)7.03ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area67.92 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity119.37 m3·mol-1ChemAxon
Polarizability45.61 Å3ChemAxon
Number of Rings5ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon

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