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Assay 99% Easing Pain Benzocaine Hydrochloride Benzocaine HCL CAS 23239-88-5

Categories Local Anesthetic Agents
Brand Name: Simeiquan
Model Number: 23239-88-5
Certification: ISO9001/ UKAS
Place of Origin: China
MOQ: 10 grams
Price: USD 1-10$ per gram
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000 kg per month
Delivery Time: 6 hours after receiving payment
Packaging Details: 10g/vial
CAS: 23239-88-5
MF: C9H11NO2.ClH
MW: 201.65
Package: negotiable
Appearance: White Crystalline Powder
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Assay 99% Easing Pain Benzocaine Hydrochloride Benzocaine HCL CAS 23239-88-5

Assay 99% Easing Pain Benzocaine Hydrochloride Benzocaine HCL CAS 23239-88-5


Basic Information

CAS23239-88-5
MFC9H11NO2.ClH
MW201.65
Packagenegotiable
AppearanceWhite Crystalline Powder
Delivery Time6 hours after receiving payment


Description

Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.


Chemical properties


Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C. The density of benzocaine is 1.17 g/cm3.


History


Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946), in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin".


Mechanism of action


Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential. The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.


Usages


Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:

  • Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
  • Otic Pain (earache)
  • Surgical or procedural local anesthesia
  • Formulations
  • Lozenges (ex. Cepacol, Mycinettes)

Adverse effects


Benzocaine is generally well-tolerated and non-toxic when applied topically as recommended.


However, there have been reports of serious, life-threatening adverse effects (e.g., seizures, coma, irregular heart beat, respiratory depression) with over-application of topical products or when applying topical products that contain high concentrations of benzocaine to the skin.


Over-application of oral anesthetics such as benzocaine can increase the risk of pulmonary aspiration by relaxing the gag-reflex and allowing regurgitated stomach contents or oral secretions to enter the airway. Applying an oral anesthetic and consuming beverages before going to bed can be particularly hazardous.

The topical use of higher concentration (14-20%) benzocaine spray products applied to the mouth or mucous membranes has been found to be a cause of methemoglobinemia, a disorder in which the amount of oxygen carried by the blood is greatly reduced. This side effect is most common in children under 2 years of age. As a result, the FDA has stated that benzocaine products should not be used in children under 2 years of age, unless directed by and supervised by a healthcare professional. Symptoms of methemoglobinemia usually occur minutes to hours of applying benzocaine, and can occur upon the first-time use or after additional use.


Benzocaine may cause allergic reactions.These include:

  1. Contact dermatitis (redness and itchiness)
  2. Anaphylaxis (rare)
  3. Other uses
  4. Jiffy Toothache Drops bottle (7.75% Benzocaine)

Benzocaine is used as a key ingredient in numerous pharmaceuticals:

  1. Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
  2. Some previous diet products such as Ayds.
  3. Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation.

Conversely, an erection will also fade faster if stimulus is interrupted.


Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.


In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.


Benzocaine is commonly found, particularly in Britain, as an impurity in street cocaine. Whilst giving a numbing effect similar to cocaine on users' gums it does not actually produce the effects of cocaine. Also benzocaine can and has been mistaken for a false positive for cocaine.


Proceeding your order

  1. Describing items you are favorable, quantities, and the destination country
  2. Confirming all details, and placing order.
  3. Receiving the quotation we send and transportation recommended
  4. Paying for the order, informing us the detailed contact information, including contact person/company, address, mobile number, ZIP code and special requirements.
  5. Notice cargo shipping usually happens after receiving payment a day later, but we will inform you the detailed arrangement and track the goods all the time.
  6. Contacting us for any problems or troubles in terms of quality and functions at any time. Your feedback will be highly appreciated!

Our Privileges

High quality with competitive price

  1. Standard: Enterprise Standard
  2. All Purity≥99%
  3. We are manufacturer and can provide high quality products with factory price


Fast and safe delivery

  1. Parcel can be sent out in 24 hours after payment. Tracking number available
  2. Secure and discreet shipment. Various transportation methods for your choice
  3. Customs pass rate ≥99%
  4. We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock for transferring


Clients throughout the world

  1. Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
  2. Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
  3. High quality,competitive price,fast delivery ,first-class service gain the trust and praise from customers.



Francis Fan
Tel:+86 755 23343413/ +86 18118734939
Skype: fwk2014
Whatsapp: +86 18118734939
E-mail: zq@chembj.com

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Quality Assay 99% Easing Pain Benzocaine Hydrochloride Benzocaine HCL CAS 23239-88-5 for sale
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